Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts

16 Aug 2017

Abstract excerpt

The retinoblastoma (RB) tumor suppressor is known as a master regulator of the cell cycle. RB is mutated or functionally inactivated in the majority of human cancers. This transcriptional regulator exerts its function in cell cycle control through its interaction with the E2F family of transcription factors and with chromatin remodelers and modifiers that contribute to the repression of genes important for cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics
Share to Ocular Oncology and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28812991
DOI: 10.3390/ijms18081776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple FrontsPMID 28812991Read ↗

The retinoblastoma gene: a prototypic and multifunctional tumor suppressor.Semantic proximity Read ↗

Chromatin regulators in retinoblastoma: Biological roles and therapeutic applicationsSemantic proximity Read ↗

The retinoblastoma protein: functions beyond the G1-S regulator.Semantic proximity Read ↗

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycleSemantic proximity Read ↗

Roles of plant retinoblastoma protein: cell cycle and beyondSemantic proximity Read ↗

Molecular Biological Research on the Pathogenic Mechanism of RetinoblastomaSemantic proximity Read ↗

Retinoblastoma: from discovery to clinical managementSemantic proximity Read ↗

Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted TherapySemantic proximity Read ↗

RB1: a prototype tumor suppressor and an enigma.Semantic proximity Read ↗

Etiology including epigenetic defects of retinoblastoma.Semantic proximity Read ↗

Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted TherapySemantic proximity Read ↗

Conserved RB functions in development and tumor suppressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.