Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.

Human molecular genetics - 1 Dec 2003

Hennah William, Varilo Teppo, Kestilä Marjo, Paunio Tiina, Arajärvi Ritva, Haukka Jari, Parker Alex, Martin Rory, Levitzky Steve, Partonen Timo, Meyer Joanne, Lönnqvist Jouko, Peltonen Leena, Ekelund Jesper

Abstract excerpt

We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes TRAX, DISC1 and DISC2, using a study sample of 458 Finnish families ascertained for schizophrenia. Two-point and haplotype association analysis revealed a significant region of interest within the DISC1 gene. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DISC1 gene
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Tissue Proteins

Share to Polymorphism, Single Nucleotide

Share to RNA, Long Noncoding

Share to RNA, Messenger

Share to Schizophrenia

Share to Sex Factors

Source

Identifiers

PMID: 14532331
DOI: 10.1093/hmg/ddg341

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.PMID 14532331Read ↗

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.Semantic proximity Read ↗

Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments.Semantic proximity Read ↗

The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.Semantic proximity Read ↗

The DISC locus in psychiatric illness.Semantic proximity Read ↗

Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1.Semantic proximity Read ↗

Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory.Semantic proximity Read ↗

Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.Semantic proximity Read ↗

Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.Semantic proximity Read ↗

Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population.Semantic proximity Read ↗

Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia.Semantic proximity Read ↗

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder.Semantic proximity Read ↗

Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.