Article
Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1.
Human molecular genetics - 1 Mar 2007
Hennah William, Tomppo Liisa, Hiekkalinna Tero, Palo Outi M, Kilpinen Helena, Ekelund Jesper, Tuulio-Henriksson Annamari, Silander Kaisa, Partonen Timo, Paunio Tiina, Terwilliger Joseph D, Lönnqvist Jouko, Peltonen Leena
Abstract excerpt
We have previously reported a robust association between an allelic haplotype of 'Disrupted in Schizophrenia 1' (DISC1) and schizophrenia in a nationwide collection of Finnish schizophrenia families. This specific DISC1 allele was later identified to associate with visual working memory, selectively in males. DISC1 association to schizophrenia has since been replicated in multiple independent study samples from...
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