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Article

Generation of "natural killer cell-escape" variants of Pichinde virus during acute and persistent infections.

Journal of virology - 1 Apr 1992

Vargas-Cortes M, O'Donnell C L, Maciaszek J W, Welsh R M

Abstract excerpt

Pichinde virus (PV) strain AN 3739 was determined to be sensitive to natural killer (NK) cells in vivo by enhanced replication in NK-cell-depleted mice. An NK-sensitive subclone (PV-NKs1) was serially passed in mice whose NK cells had previously been activated by an interferon inducer, and two plaque isolates were shown to be resistant to NK cells but not to interferon. Inoculation of...

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Identifiers

PMID: 1372371
DOI: 10.1128/JVI.66.4.2532-2535.1992
PMCID: PMC289053

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