Generation of "natural killer cell-escape" variants of Pichinde virus during acute and persistent infections.

doi:10.1128/JVI.66.4.2532-2535.1992

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Article

Generation of "natural killer cell-escape" variants of Pichinde virus during acute and persistent infections.

Journal of virology - 1 Apr 1992

Vargas-Cortes M, O'Donnell C L, Maciaszek J W, Welsh R M

Abstract excerpt

Pichinde virus (PV) strain AN 3739 was determined to be sensitive to natural killer (NK) cells in vivo by enhanced replication in NK-cell-depleted mice. An NK-sensitive subclone (PV-NKs1) was serially passed in mice whose NK cells had previously been activated by an interferon inducer, and two pl...

Topics

Acute Disease
Animals
Arenaviridae
Arenaviridae Infections
Chronic Disease
Genetic Variation
Interferons
Killer Cells, Natural
Mice
Mice, Inbred C3H
Mice, Inbred C57BL

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