Article
Mutations in West Nile virus nonstructural proteins that facilitate replicon persistence in vitro attenuate virus replication in vitro and in vivo.
Virology - 20 Jul 2007
Rossi Shannan L, Fayzulin Rafik, Dewsbury Nathan, Bourne Nigel, Mason Peter W
Abstract excerpt
West Nile virus (WNV) infections in vertebrates are generally acute but persistent infections have been observed. To investigate the ability of WNV to produce persistent infections, we forced subgenomic WNV replicons to replicate within a cell without causing cell death. Detailed analyses of these cell-adapted genomes revealed mutations within the nonstructural protein genes NS2A (D73H, M108K), NS3 (117Kins),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.