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Article

Coexistence in lactate dehydrogenase-elevating virus pools of variants that differ in neuropathogenicity and ability to establish a persistent infection.

Journal of virology - 1 Apr 1997

Chen Z, Rowland R R, Anderson G W, Palmer G A, Plagemann P G

Abstract excerpt

Neuropathogenic isolates of lactate dehydrogenase-elevating virus (LDV) differ from nonneuropathogenic isolates in their unique ability to infect anterior horn neurons of immunosuppressed C58 and AKR mice and cause paralytic disease (age-dependent poliomyelitis [ADPM]). However, we and others have found that neuropathogenic LDVs fail to retain their neuropathogenicity during persistent infections of both...

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Identifiers

PMID: 9060649
DOI: 10.1128/JVI.71.4.2913-2920.1997
PMCID: PMC191418

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