Article
Escape of mutant double-stranded DNA virus from innate immune control.
Immunity - 1 Jun 2004
French Anthony R, Pingel Jeanette T, Wagner Markus, Bubic Ivan, Yang Liping, Kim Sungjin, Koszinowski Ulrich, Jonjic Stipan, Yokoyama Wayne M
Abstract excerpt
As innate immune system components, natural killer (NK) cells respond rapidly to infections and effectively control replication of pathogens, including murine cytomegalovirus (MCMV), a double-stranded DNA beta-herpesvirus. In the absence of NK cell control, MCMV infection results in early mortality due to uncontrolled viral replication. However, here we show that even in the face of initial NK cell control, there...
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