Cloning and characterization of human immunodeficiency virus type 1 variants diminished in the ability to induce syncytium-independent cytolysis.

doi:10.1128/JVI.64.8.3792-3803.1990

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Article

Cloning and characterization of human immunodeficiency virus type 1 variants diminished in the ability to induce syncytium-independent cytolysis.

Journal of virology - 1 Aug 1990

Stevenson M, Haggerty S, Lamonica C, Mann A M, Meier C, Wasiak A

Abstract excerpt

The phenomenon of interference was exploited to isolate low-abundance noncytopathic human immunodeficiency virus type 1 (HIV-1) variants from a primary HIV-1 isolate from an asymptomatic HIV-1-seropositive hemophiliac. Successive rounds of virus infection of a cytolysis-susceptible CD4+ cell line and isolation of surviving cells resulted in selective amplification of an HIV-1 variant reduced in the ability to...

Topics

Amino Acid Sequence
Base Sequence
Cell Line
Cell Transformation, Viral
Cloning, Molecular
DNA, Viral
Fluorescent Antibody Technique
Genetic Variation
Giant Cells
Glycosylation
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Human T-lymphotropic virus 1

Humans

Information Systems

Kinetics

Molecular Sequence Data

Nucleic Acid Hybridization

Source

Open in PubMed Open full text

Identifiers

PMID: 1695254
DOI: 10.1128/JVI.64.8.3792-3803.1990
PMCID: PMC249674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1695254-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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