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Article

Characterization of persistent poliovirus mutants selected in human neuroblastoma cells.

Virology - 1 Feb 1991

Pelletier I, Couderc T, Borzakian S, Wyckoff E, Crainic R, Ehrenfeld E, Colbere-Garapin F

Abstract excerpt

Six Sabin-derived persistent poliovirus mutants were selected in human neuroblastoma IMR-32 cells. The mutants had a titer 30 to 10(5) times lower in nonneural HEp-2c cells than in IMR-32 cells. When the growth cycles of persistent viruses in the two cell lines were compared, the most striking feature was a delay of 2 to 4 hr in virus release from HEp-2c cells. In Hep-2c cells, type 1 mutants could spontaneously...

Topics

Blotting, Northern
Cell Line
Genes, Viral
Humans
Mutation
Neuroblastoma
Phenotype
Poliovirus
RNA, Viral

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1846495
DOI: 10.1016/0042-6822(91)90086-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1846495-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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