Article
Rapid emergence of escape mutants following infection with murine cytomegalovirus in immunodeficient mice.
Clinical immunology (Orlando, Fla.) - 1 Apr 2005
French Anthony R, Pingel Jeanette T, Kim Sungjin, Yang Liping, Yokoyama Wayne M
Abstract excerpt
Natural killer (NK) cells play a crucial role in the initial host defense against pathogens such as murine cytomegalovirus (MCMV). They respond rapidly and effectively control pathogen replication while the adaptive immune system is being activated. However, in the absence of an adaptive immune system, an effective initial NK cell response is not sufficient for long-term pathogen control as demonstrated by the...
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