Article
Mutational analyses of lymphocyte differentiation.
Harvey lectures - 1 Jan 2000
Alt F W
Abstract excerpt
The site-specific recombination mechanism responsible for the assembly of antigen receptor variable region genes is only employed in lymphocyte development. Gene-targeted and other types of mutational analyses have implicated at least seven distinct gene products, some lymphoid-specific and others more generally expressed, as involved in aspects of this process. Mutation of the lymphocyte-specific activities...
Topics
- Animals
- Cell Differentiation
- Gene Rearrangement, B-Lymphocyte
- Gene Rearrangement, T-Lymphocyte
- Humans
- Immunoglobulin Class Switching
- Lymphocytes
- Mice
- Mutation
- Recombination, Genetic