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Article

Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.

The Journal of experimental medicine - 24 Dec 2007

Bates Jamie Geier, Cado Dragana, Nolla Hector, Schlissel Mark S

Abstract excerpt

Complete IgHC gene rearrangement occurs only in B cells in a stage-specific and ordered manner. We used gene targeting to reposition a distal V(H) gene segment to a region just 5' of the D(H) gene cluster and found its activation to be highly dependent on the chromosomal domain within which it resides. The targeted V(H) gene segment rearranged at a higher frequency than its endogenous counterpart, its...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18056289
DOI: 10.1084/jem.20071787
PMCID: PMC2150984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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