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Article

Site Specific and Orientation Dependent CTCF Binding Determines VDJ Recombination at Murine Tcrb Locus.

Molecular and cellular biology - 1 Jan 2025

Yadav Monika, Sharma Samriddhi, Rajalekshmi S R, Bhasin Nidhi, Yimdjo Jeanne, Pfeifer Karl, Srivastava Madhulika

Abstract excerpt

CTCF is a multifunctional protein that mediates long-range cis-DNA interactions in mammalian genomes. Chromatin architecture governs spatial and functional interactions of gene regulatory elements at various loci and is impacted by the ability of CTCF to restrict cohesin complex dependent chromatin extrusion. In addition, at antigen receptor loci, long-range interactions facilitate spatial proximity of gene...

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Identifiers

PMID: 40965216
DOI: 10.1080/10985549.2025.2553650

Genes

CTCF
CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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