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Article

Regulated progression of a cultured pre-B-cell line to the B-cell stage.

Nature - 1 Jan 2000

Reth M G, Ammirati P, Jackson S, Alt F W

Abstract excerpt

The variable (V) regions of heavy and light immunoglobulin chains are encoded by multiple germline DNA elements which are assembled into complete variable-region genes in precursor(pre-) B lymphocytes. The heavy-chain V region (VH) is assembled from three separate germline DNA elements, the variable (VH), diversity (D) and joining (JH) segments; whereas light-chain variable regions of either the kappa or lambda...

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PMID: 3930970
DOI: 10.1038/317353a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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