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Article

Regulated progression of a cultured pre-B-cell line to the B-cell stage.

Nature - 1 Jan 2000

Reth M G, Ammirati P, Jackson S, Alt F W

Abstract excerpt

The variable (V) regions of heavy and light immunoglobulin chains are encoded by multiple germline DNA elements which are assembled into complete variable-region genes in precursor(pre-) B lymphocytes. The heavy-chain V region (VH) is assembled from three separate germline DNA elements, the variable (VH), diversity (D) and joining (JH) segments; whereas light-chain variable regions of either the kappa or lambda...

Topics

Abelson murine leukemia virus
Alleles
Animals
B-Lymphocytes
Bone Marrow Cells
Cell Transformation, Viral
Clone Cells
Genes
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Source

Identifiers

PMID: 3930970
DOI: 10.1038/317353a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3930970-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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