Loss of heterozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas.

doi:10.1016/0140-6736(92)93214-8

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Article

Loss of heterozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas.

Lancet (London, England) - 18 Jul 1992

Kaelbling M, Burk R D, Atkin N B, Johnson A B, Klinger H P

Abstract excerpt

Inactivation of the protein product of the wild-type tumour suppressor gene p53 through complexing of the protein with the E6 oncoprotein of human papillomaviruses (HPV) in HPV-infected cells is thought to be important in the aetiology of cervical carcinoma. Mutations of p53 have also been report...

Topics

Chromosome Aberrations
Chromosomes, Human, 16-18
DNA Probes, HPV
Female
Genes, p53
Humans
Mutation
Polymerase Chain Reaction
Uterine Cervical Neoplasms

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