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Article

Loss of heterozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas.

Lancet (London, England) - 18 Jul 1992

Kaelbling M, Burk R D, Atkin N B, Johnson A B, Klinger H P

Abstract excerpt

Inactivation of the protein product of the wild-type tumour suppressor gene p53 through complexing of the protein with the E6 oncoprotein of human papillomaviruses (HPV) in HPV-infected cells is thought to be important in the aetiology of cervical carcinoma. Mutations of p53 have also been reported in HPV-negative carcinomas, and we now demonstrate loss of heterozygosity (LOH) of chromosome region 17p13 (in which...

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Source

Identifiers

PMID: 1352566
DOI: 10.1016/0140-6736(92)93214-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of heterozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas.PMID 1352566Read ↗

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Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas.Semantic proximity Read ↗

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