Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement of wild-type p53 protein for maintenance of chromosomal integrity

1 Jan 2000

Abstract excerpt

Chromosomal double-strand breaks (DSBs) occurring in mammalian cells can initiate genomic instability, and their misrepairs result in chromosomal deletion, amplification, and translocation, common findings in human tumors. The tumor-suppressor protein p53 is involved in maintaining genomic stability. In this study, we demonstrate that the deficiency of wild-type p53 protein may allow unrepaired DSBs to initiate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10972990
DOI: 10.1002/1098-2744(200008)28:4<203::aid-mc3>3.0.co;2-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of wild-type p53 protein for maintenance of chromosomal integrityPMID 10972990Read ↗

Illegitimate recombination leading to allelic loss and unbalanced translocation in p53-mutated human lymphoblastoid cells.Semantic proximity Read ↗

Generation of loss of heterozygosity and its dependency on p53 status in human lymphoblastoid cells.Semantic proximity Read ↗

A Critical Role for p53 during the HPV16 Life CycleSemantic proximity Read ↗

A critical role for E2-p53 interaction during the HPV16 life cycleSemantic proximity Read ↗

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.Semantic proximity Read ↗

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cellsSemantic proximity Read ↗

HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures.Semantic proximity Read ↗

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Semantic proximity Read ↗

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activationSemantic proximity Read ↗

Functional consequences of directed mutations in human papillomavirus E6 proteins: abrogation of p53-mediated cell cycle arrest correlates with p53 binding and degradation in vitro.Semantic proximity Read ↗

Genetic instability leads to loss of both p53 alleles in a human glioblastoma.Semantic proximity Read ↗

High-Risk Alphapapillomavirus Oncogenes Impair the Homologous Recombination PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.