Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma.

Human molecular genetics - 1 Nov 1992

Nakatsuru S, Yanagisawa A, Ichii S, Tahara E, Kato Y, Nakamura Y, Horii A

Abstract excerpt

We searched for somatic mutations of the adenomatous polyposis coli (APC) gene in DNA samples isolated from 57 sporadic gastric cancers, by means of a ribonuclease (RNase) protection analysis coupled with DNA amplification by the polymerase chain reaction (PCR). Examining 30% of the APC coding region, including a region where somatic mutations in colorectal tumors are known to be clustered, we detected somatic...

Topics

Adenocarcinoma
Adenocarcinoma, Mucinous
Base Sequence
Cell Differentiation
DNA Mutational Analysis
DNA, Neoplasm
Genes, APC
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

Source

Identifiers

PMID: 1338691
DOI: 10.1093/hmg/1.8.559

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1338691-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma.PMID 1338691Read ↗

The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.Semantic proximity Read ↗

Somatic mutations of the APC gene in precancerous lesion of the stomach.Semantic proximity Read ↗

Frequent somatic mutations of the APC gene in human pancreatic cancer.Semantic proximity Read ↗

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.Semantic proximity Read ↗

Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients.Semantic proximity Read ↗

Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.Semantic proximity Read ↗

Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues.Semantic proximity Read ↗

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.Semantic proximity Read ↗

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

Monoallelic methylation of the APC promoter is altered in normal gastric mucosa associated with neoplastic lesions.Semantic proximity Read ↗

Mutations of the APC gene occur during early stages of gastric adenoma development.Semantic proximity Read ↗

Mutations of the adenomatous polyposis coli gene in the mutation cluster region: comparison of human pancreatic and colorectal cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.