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Article

The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.

Cancer research - 1 Jun 1992

Horii A, Nakatsuru S, Miyoshi Y, Ichii S, Nagase H, Kato Y, Yanagisawa A, Nakamura Y

Abstract excerpt

Although gastric cancer is the most common cancer in the world, genetic changes during its carcinogenesis are not well understood. Since some gastric cancers are considered to originate from the intestinal metaplasia, it is likely that the adenomatous polyposis coli (APC) gene, the mutation of which causes adenomatous polyps in the colon, is associated with carcinogenesis of gastric cancer. Based on this idea,...

Topics

Adenocarcinoma
Adenomatous Polyposis Coli
Base Sequence
Chromosome Deletion
Codon
DNA, Neoplasm
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Reference Values

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

Source

Identifiers

PMID: 1317264

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1317264-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.PMID 1317264Read ↗

Somatic mutations of the APC gene in precancerous lesion of the stomach.Semantic proximity Read ↗

Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma.Semantic proximity Read ↗

Frequent somatic mutations of the APC gene in human pancreatic cancer.Semantic proximity Read ↗

The role of the adenomatous polyposis coli (APC) gene in human cancers.Semantic proximity Read ↗

Mutations of the APC (adenomatous polyposis coli) gene.Semantic proximity Read ↗

Mutations of the APC (adenomatous polyposis coli) gene in human cancers.Semantic proximity Read ↗

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.Semantic proximity Read ↗

Mutations of the adenomatous polyposis coli gene in the mutation cluster region: comparison of human pancreatic and colorectal cancers.Semantic proximity Read ↗

Mutations of the APC gene occur during early stages of gastric adenoma development.Semantic proximity Read ↗

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.Semantic proximity Read ↗

APC germline mutations identified in Czech patients with familial adenomatous polyposis.Semantic proximity Read ↗

Novel mutations of the APC gene in familial adenomatous polyposis in Greek patients.Semantic proximity Read ↗

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