Article
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
Proceedings of the National Academy of Sciences of the United States of America - 15 May 1992
Miyoshi Y, Ando H, Nagase H, Nishisho I, Horii A, Miki Y, Mori T, Utsunomiya J, Baba S, Petersen G
Abstract excerpt
We searched for germ-line mutations of the APC gene in 79 unrelated patients with familial adenomatous polyposis using a ribonuclease protection analysis coupled with polymerase chain reaction amplifications of genomic DNA. Mutations were found in 53 patients (67%); 28 of the mutations were small...
Topics
- Adenoma
- Adenomatous Polyposis Coli
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 5
- Codon
- DNA, Neoplasm
- Exons
- Frameshift Mutation
- Genes, Tumor Suppressor
- Genetic Linkage
- Humans
- Japan
- Molecular Sequence Data