Article
Mutations of the APC gene occur during early stages of gastric adenoma development.
Cancer research - 1 Mar 1994
Tamura G, Maesawa C, Suzuki Y, Tamada H, Satoh M, Ogasawara S, Kashiwaba M, Satodate R
Abstract excerpt
Mutations of the adenomatous polyposis coli (APC) gene have recently been shown to play an important role in colorectal tumorigenesis. We investigated mutations of the APC gene in 30 gastric adenomas obtained endoscopically. Mutations of the APC gene were examined by polymerase chain reaction-single-strand conformation polymorphism analysis followed by sequencing of the polymerase chain reaction products....
Topics
- Adenoma
- Base Sequence
- DNA, Single-Stranded
- Genes, APC
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction
- Stomach Neoplasms