Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.

doi:10.1007/BF00195774

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Article

Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.

Virchows Archiv : an international journal of pathology - 1 Jan 1994

Ogasawara S, Maesawa C, Tamura G, Satodate R

Abstract excerpt

The adenomatous polyposis coli (APC) gene is the target of the loss of chromosome 5q heterozygosity observed frequently in gastrointestinal tract carcinomas and is inactivated in these carcinomas. We screened 94 gastrointestinal tract carcinomas for APC mutations, by polymerase chain reaction sin...

Topics

Base Sequence
Carcinoma
Colorectal Neoplasms
DNA, Neoplasm
Esophageal Neoplasms
Genes, APC
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Sequence Analysis, DNA
Stomach Neoplasms

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