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Article

Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.

Virchows Archiv : an international journal of pathology - 1 Jan 1994

Ogasawara S, Maesawa C, Tamura G, Satodate R

Abstract excerpt

The adenomatous polyposis coli (APC) gene is the target of the loss of chromosome 5q heterozygosity observed frequently in gastrointestinal tract carcinomas and is inactivated in these carcinomas. We screened 94 gastrointestinal tract carcinomas for APC mutations, by polymerase chain reaction single-strand conformation polymorphism (SSCP) analysis. Mutations were detected in 8 of 21 (38%) colorectal carcinomas in...

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Identifiers

PMID: 8055154
DOI: 10.1007/BF00195774

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.PMID 8055154Read ↗

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Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.Semantic proximity Read ↗

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.Semantic proximity Read ↗

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