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Article

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.

International journal of cancer - 21 Oct 1993

McKie A B, Filipe M I, Lemoine N R

Abstract excerpt

Abnormalities affecting tumour suppressor genes on chromosome 5q21 are increasingly recognised as important in the pathogenesis of a variety of human cancers, particularly of the gastrointestinal tract. We have examined a series of gastric and pancreatic cancers from European patients for loss of heterozygosity (LOH) of markers within and around the APC and MCC genes on chromosome 5q21 using restriction fragment...

Read the complete abstract on PubMed

Topics

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Share to Adenocarcinoma
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to APC gene

Share to Genes, Tumor Suppressor

Share to Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8406987
DOI: 10.1002/ijc.2910550414

Genes

APC
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.PMID 8406987Read ↗

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.Semantic proximity Read ↗

Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.Semantic proximity Read ↗

Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis.Semantic proximity Read ↗

Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.Semantic proximity Read ↗

MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.Semantic proximity Read ↗

Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.Semantic proximity Read ↗

Loss of heterozygosity at 5q21 in non-small cell lung cancer: a frequent event but without evidence of apc mutation.Semantic proximity Read ↗

Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas.Semantic proximity Read ↗

APC gene mutations in the mutation cluster region are rare in esophageal cancers.Semantic proximity Read ↗

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.Semantic proximity Read ↗

Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.Semantic proximity Read ↗

Evidence for a common molecular pathogenesis in colorectal, gastric, and pancreatic cancer.Semantic proximity Read ↗

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