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Article

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

Cancer research - 15 Aug 2000

Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinado M A, Gonzalez S, Tarafa G, Sidransky D, Meltzer S J, Baylin S B, Herman J G

Abstract excerpt

Germ-line mutations in the tumor suppressor gene APC are associated with hereditary familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic colorectal tumors. We now report that methylation in the promoter region of this gene constitutes an alternative mechanism for gene inactivation in colon and other tumors of the gastrointestinal tract. The APC promoter is hypermethylated in 18% of...

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Identifiers

PMID: 10969779

Genes

APC
FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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