Article
Mutations of the adenomatous polyposis coli gene in the mutation cluster region: comparison of human pancreatic and colorectal cancers.
International journal of cancer - 1 Oct 1994
Yashima K, Nakamori S, Murakami Y, Yamaguchi A, Hayashi K, Ishikawa O, Konishi Y, Sekiya T
Abstract excerpt
We analyzed the adenomatous polyposis coli (APC) tumor-suppressor gene as one of the possible genes mutated in human pancreatic carcinomas. DNAs from 39 surgical specimens were subjected to single-strand conformation polymorphism analysis of polymerase chain reaction products and the mutation clu...
Topics
- Adenomatous Polyposis Coli
- Adult
- Aged
- Base Sequence
- Colorectal Neoplasms
- DNA, Neoplasm
- Female
- Gene Frequency
- Genes, APC
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Genetic