Article
Frequent somatic mutations of the APC gene in human pancreatic cancer.
Cancer research - 1 Dec 1992
Horii A, Nakatsuru S, Miyoshi Y, Ichii S, Nagase H, Ando H, Yanagisawa A, Tsuchiya E, Kato Y, Nakamura Y
Abstract excerpt
The APC (adenomatous polyposis coli) gene is responsible for familial adenomatous polyposis and is also associated with the development of sporadic tumors of the colon and stomach. To investigate whether or not mutations of APC play any role in tumors arising in other organs, we examined somatic mutations of this gene in sporadic (nonfamilial) renal cell carcinomas, hepatocellular carcinomas, and cancers of the...
Topics
- Base Sequence
- Codon
- Colonic Polyps
- DNA Mutational Analysis
- DNA, Neoplasm
- Gene Amplification
- Humans
- Molecular Sequence Data
- Mutation
- Pancreatic Neoplasms
- Polymerase Chain Reaction