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Article

Detection of mutations in the p53 gene in human head and neck carcinomas by single strand conformation polymorphism analysis.

Cancer letters - 24 Dec 1992

Chang Y S, Lin Y J, Tsai C N, Shu C H, Tsai M S, Choo K B, Liu S T

Abstract excerpt

Using the polymerase chain reaction (PCR)-based single strand conformation polymorphism (SSCP) analysis, we have examined the highly conserved regions of the p53 gene in 58 biopsy samples of head and neck tumors. Mutations were found in 13/58 (23%) tumor specimens, but not in 6 normal tissues. Te...

Topics

Base Sequence
Carcinoma
DNA, Neoplasm
Genes, p53
Head and Neck Neoplasms
Herpesvirus 4, Human
Humans
Molecular Sequence Data
Mutation
Nasopharyngeal Neoplasms
Papillomaviridae
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Tumor Virus Infections

Source

Identifiers

PMID: 1336431
DOI: 10.1016/0304-3835(92)90140-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1336431-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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