Article
p53 gene mutations in esophageal cancer detected by polymerase chain reaction single-strand conformation polymorphism analysis.
Japanese journal of cancer research : Gann - 1 Jun 1992
Tamura G, Maesawa C, Suzuki Y, Satodate R, Ishida K, Saito K
Abstract excerpt
Mutations of the p53 gene play an important role in the development of common human malignancies. We investigated mutations of this gene in 26 surgical specimens of esophageal cancer using the polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) analysis. The results were...
Topics
- Base Sequence
- DNA, Neoplasm
- Esophageal Neoplasms
- Flow Cytometry
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Tumor Suppressor Protein p53