Article
Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung.
Cancer research - 1 Sept 1992
Kishimoto Y, Murakami Y, Shiraishi M, Hayashi K, Sekiya T
Abstract excerpt
Aberrations of the p53 gene in 115 surgical specimens of non-small cell carcinomas of the lung were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products. Structural abnormalities of the p53 gene were observed in 60 tumors (52%), i.e., 8 of 14 large cell carcinomas, 24 of 58 adenocarcinomas, 25 of 37 squamous cell carcinomas, and 3 of 6 adenosquamous carcinomas. Direct...
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