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Article

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung.

Cancer research - 1 Sept 1992

Kishimoto Y, Murakami Y, Shiraishi M, Hayashi K, Sekiya T

Abstract excerpt

Aberrations of the p53 gene in 115 surgical specimens of non-small cell carcinomas of the lung were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products. Structural abnormalities of the p53 gene were observed in 60 tumors (52%), i.e., 8 of 14 large cell carcinomas, 24 of 58 adenocarcinomas, 25 of 37 squamous cell carcinomas, and 3 of 6 adenosquamous carcinomas. Direct...

Topics

Base Sequence
Carcinoma, Non-Small-Cell Lung
Genes, p53
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1324794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1324794-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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