Article
Tumor suppressor p53 gene mutation in squamous cell carcinoma of the larynx.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 1996
Sarkar F H, Sakr W A, Li Y W, Jacobs J, Crissman J D
Abstract excerpt
Using polymerase chain reaction (PCR)-SSCP (single-strand conformation polymorphism) and PCR-DNA sequencing analysis, we screened 61 cases of laryngeal squamous cell carcinoma for mutations in exons 5-8 of the p53 gene. Mutations were found in 31.3% (19 of 61) of the laryngeal cancers. Seventeen of 19 (84.2%) cases showing p53 gene mutations were stage III and IV, which suggests that p53 gene mutation is a rather...
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