Tumor suppressor p53 gene mutation in squamous cell carcinoma of the larynx.

doi:10.1097/00019606-199609000-00009

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Article

Tumor suppressor p53 gene mutation in squamous cell carcinoma of the larynx.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 1996

Sarkar F H, Sakr W A, Li Y W, Jacobs J, Crissman J D

Abstract excerpt

Using polymerase chain reaction (PCR)-SSCP (single-strand conformation polymorphism) and PCR-DNA sequencing analysis, we screened 61 cases of laryngeal squamous cell carcinoma for mutations in exons 5-8 of the p53 gene. Mutations were found in 31.3% (19 of 61) of the laryngeal cancers. Seventeen...

Topics

Biomarkers, Tumor
Carcinoma, Squamous Cell
Genes, p53
Humans
Laryngeal Neoplasms
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Prognosis

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