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Article

Mutations in the p53 tumor suppressor gene in human cutaneous squamous cell carcinomas.

Molecular carcinogenesis - 1 Jan 1991

Pierceall W E, Mukhopadhyay T, Goldberg L H, Ananthaswamy H N

Abstract excerpt

In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent cloning and sequencing of PCR-amplified exon 7 DNA from these two tumors revealed that one had a G----A transition at the...

Topics

Base Sequence
Carcinoma, Squamous Cell
Genes, Tumor Suppressor
Genes, ras
Humans
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Polymorphism, Genetic
Skin Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 1793482
DOI: 10.1002/mc.2940040606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1793482-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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