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Article

Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products.

Oncogene - 1 Aug 1991

Mashiyama S, Murakami Y, Yoshimoto T, Sekiya T, Hayashi K

Abstract excerpt

Single-strand conformation polymorphism analysis of polymerase chain reaction products (PCR-SSCP analysis) was used for detection of mutations of the p53 gene in surgical specimens of human brain tumors. Six of 45 brain tumors showed mobility shifts in the analyses. These six tumors also showed loss of a normal allele. The samples were examined further by direct sequencing. Results showed that four of them had...

Topics

Astrocytoma
Base Sequence
Brain Neoplasms
Chromosome Deletion
DNA, Neoplasm
DNA, Single-Stranded
Genes, p53
Glioma
Humans
Meningioma
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 1886708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1886708-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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