The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.

doi:10.1002/ijc.2910520606

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Article

The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.

International journal of cancer - 2 Dec 1992

Sakai E, Rikimaru K, Ueda M, Matsumoto Y, Ishii N, Enomoto S, Yamamoto H, Tsuchida N

Abstract excerpt

The frequencies of mutations in the p53 tumor-suppressor gene and ras proto-oncogenes were investigated systematically in surgically resected oral squamous-cell carcinomas (SCCs) using single-strand conformation polymorphism (SSCP) and/or dot-blot hybridization analysis of DNA fragments which had been amplified by the polymerase chain reaction (PCR). p53 gene mutations, within the region of exons 5 to 8, were...

Topics

Adult
Aged
Base Sequence
Carcinoma, Squamous Cell
Codon
Female
Genes, p53
Genes, ras
Humans
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mouth Neoplasms

Mutation

Nucleic Acid Conformation

Nucleic Acid Hybridization

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 1459726
DOI: 10.1002/ijc.2910520606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1459726-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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