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Article

Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.

The Journal of biological chemistry - 28 Nov 2003

Billich Andreas, Bornancin Frederic, Dévay Piroska, Mechtcheriakova Diana, Urtz Nicole, Baumruker Thomas

Abstract excerpt

The immunomodulatory drug FTY720 is phosphorylated in vivo, and the resulting FTY720 phosphate as a ligand for sphingosine-1-phosphate receptors is responsible for the unique biological effects of the compound. So far, phosphorylation of FTY720 by murine sphingosine kinase (SPHK) 1a had been documented. We found that, while FTY720 is also phosphorylated by human SPHK1, the human type 2 isoform phosphorylates the...

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Identifiers

PMID: 13129923
DOI: 10.1074/jbc.M307687200

Genes

SPHK2
SPHK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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