Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

16 Feb 2007

Abstract excerpt

FTY720 (fingolimod; 2-amino-2[2-(4-octylphenyl)ethyl]-1,3-propanediol, Novartis) is the prototype of a new generation of immunomodulators. The drug is the result of extensive chemical derivatisation based on the natural product myriocin, isolated from the ascomycete Isaria sinclairii. FTY720 bears structural similarity to sphingosine, a naturally occurring sphingolipid. As with sphingosine, FTY720 is effectively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Research on Leishmaniasis Studies
Share to Sphingolipid Metabolism and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17302523
DOI: 10.1517/13543784.16.3.283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosisPMID 17302523Read ↗

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod.Semantic proximity Read ↗

Sphingosine‐1‐phosphate receptor 1 signalling in T cells: trafficking and beyondSemantic proximity Read ↗

The Impact of Sphinogosine-1-Phosphate Receptor Modulators on COVID-19 and SARS-CoV-2 VaccinationSemantic proximity Read ↗

Rescue of In Vitro Models of CSF1R-Related Adult-Onset Leukodystrophy by Iluzanebart: Mechanisms and Therapeutic Implications of TREM2 AgonismSemantic proximity Read ↗

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.Semantic proximity Read ↗

Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.Semantic proximity Read ↗

A Novel Function of Sphingolipid Signaling via S1PR3 in Hematopoietic and Leukemic Stem CellsSemantic proximity Read ↗

Masitinib is an oral, brain penetrant inhibitor of microglial and mast cell activity with neuroprotective potential in progressive forms of multiple sclerosisSemantic proximity Read ↗

Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis.Semantic proximity Read ↗

Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disordersSemantic proximity Read ↗

Production of α-galactosylceramide by a prominent member of the human gut microbiota.Semantic proximity Read ↗

Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory ActivitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.