Article
Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase.
The EMBO journal - 15 Mar 1995
Belka C, Wiegmann K, Adam D, Holland R, Neuloh M, Herrmann F, Krönke M, Brach M A
Abstract excerpt
TNF-alpha mediates proliferation, functional activation and apoptotic death of cells depending upon its concentration and target cell type. The signaling pathways used by TNF-alpha to mount these responses are, at present, not completely understood. We report here that TNF-alpha promotes dose- and time-dependent phosphorylation and activation of the c-raf-1 kinase engaging the type I p55 TNF receptor (TNF-R)....
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, CD
- Cells, Cultured
- Enzyme Activation
- Fibroblasts
- Genes, Reporter
- Humans
- Hydrogen-Ion Concentration
- Mice
- Monocytes