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Article

Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase.

The EMBO journal - 15 Mar 1995

Belka C, Wiegmann K, Adam D, Holland R, Neuloh M, Herrmann F, Krönke M, Brach M A

Abstract excerpt

TNF-alpha mediates proliferation, functional activation and apoptotic death of cells depending upon its concentration and target cell type. The signaling pathways used by TNF-alpha to mount these responses are, at present, not completely understood. We report here that TNF-alpha promotes dose- and time-dependent phosphorylation and activation of the c-raf-1 kinase engaging the type I p55 TNF receptor (TNF-R)....

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Identifiers

PMID: 7720706
DOI: 10.1002/j.1460-2075.1995.tb07099.x
PMCID: PMC398193

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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