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Article

Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.

The Journal of biological chemistry - 8 Mar 2002

Xia Pu, Wang Lijun, Moretti Paul A B, Albanese Nathaniel, Chai Fugui, Pitson Stuart M, D'Andrea Richard J, Gamble Jennifer R, Vadas Mathew A

Abstract excerpt

Tumor necrosis factor-alpha (TNF) receptor-associated factor 2 (TRAF2) is one of the major mediators of TNF receptor superfamily transducing TNF signaling to various functional targets, including activation of NF-kappa B, JNK, and antiapoptosis. We investigated how TRAF2 mediates differentially the distinct downstream signals. We now report a novel mechanism of TRAF2-mediated signal transduction revealed by an...

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Source

Identifiers

PMID: 11777919
DOI: 10.1074/jbc.M111423200

Genes

TRAF2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.PMID 11777919Read ↗

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