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Article

Mouse Sphingosine Kinase 1a Is Negatively Regulated through Conventional PKC-Dependent Phosphorylation at S373 Residue.

PloS one - 1 Jan 2015

Oh Yong-Seok, Bae Sun Sik, Park Jong Bae, Ha Sang Hoon, Ryu Sung Ho, Suh Pann-Ghill

Abstract excerpt

Sphingosine kinase is a lipid kinase that converts sphingosine into sphingosine-1-phosphate, an important signaling molecule with intracellular and extracellular functions. Although diverse extracellular stimuli influence cellular sphingosine kinase activity, the molecular mechanisms underlying its regulation remain to be clarified. In this study, we investigated the phosphorylation-dependent regulation of mouse...

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Identifiers

PMID: 26642194
DOI: 10.1371/journal.pone.0143695
PMCID: PMC4671553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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