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Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2008

Cai Qiuyin, Kataoka Nobuhiko, Li Chun, Wen Wanqing, Smith Jeffrey R, Gao Yu-Tang, Shu Xiao Ou, Zheng Wei

Abstract excerpt

Estrogens play a central role in the etiology of breast cancer. The CYP19A1 gene encodes aromatase, a key enzyme in the biosynthesis of estrogens. Several single nucleotide polymorphisms (SNP) or haplotypes in the CYP19A1 gene have been evaluated in relation to breast cancer risk. However, the results have been inconsistent. In this study, we constructed haplotypes of the CYP19A1 gene using 19 haplotype-tagging...

Topics

Adult
Aromatase
Breast Neoplasms
Case-Control Studies
China
Female
Haplotypes
Humans
Middle Aged
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Postmenopause

Premenopause

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 18199708
DOI: 10.1158/1055-9965.EPI-07-0688
PMCID: PMC2633134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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