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Breast Cancer Susceptibility: Meta-Analysis of Cytochrome P450 2C19 (CYP2C19) and Estrogen Receptor-1 (ESR1) Genetic Variants.

Cancer investigation - 1 Feb 2026

Shibi Anilkumar Anu, Thomas Sheena Mariam, Veerabathiran Ramakrishnan

Abstract excerpt

INTRODUCTION: Breast Cancer (BC) is a leading cancer among women, influenced by genetic polymorphisms. This meta-analysis examines CYP2C19 (rs4244285) and ESR1 (rs2234693) polymorphisms and BC susceptibility. METHODOLOGY: A PRISMA-guided search analyzed genotypic and allelic frequencies across six CYP2C19 and nine ESR1 studies, with quality assessed by the Newcastle-Ottawa Scale and Hardy-Weinberg Equilibrium,...

Topics

Humans
Breast Neoplasms
Female
Genetic Predisposition to Disease
Cytochrome P-450 CYP2C19
Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Genotype

Gene Frequency

Source

Identifiers

PMID: 41340570
DOI: 10.1080/07357907.2025.2596854

Genes

CYP2C19
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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