Article
A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches.
Breast cancer research and treatment - 1 Apr 2007
Olson Janet E, Ingle James N, Ma Cynthia X, Pelleymounter Linda L, Schaid Daniel J, Pankratz V Shane, Vierkant Robert A, Fredericksen Zachary S, Wu Yanhong, Couch Fergus J, Vachon Celine M, Sellers Thomas A, Weinshilboum Richard M
Abstract excerpt
BACKGROUND: Numerous studies point to a positive relationship between elevated levels of estrogens and increased risk of breast. Androgens are converted to estrogens by the aromatase enzyme, which is encoded by the CYP19 gene. We recently published resequencing data on 88 polymorphisms identified in that gene. The hypothesis tested in this study was that polymorphisms, or haplotypes, in CYP19 are related to risk...
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