Article
Associations between CYP19A1 polymorphisms, Native American ancestry, and breast cancer risk and mortality: the Breast Cancer Health Disparities Study.
Cancer causes & control : CCC - 1 Nov 2014
Boone Stephanie D, Baumgartner Kathy B, Baumgartner Richard N, Connor Avonne E, Pinkston Christina M, Rai Shesh N, Riley Elizabeth C, Hines Lisa M, Giuliano Anna R, John Esther M, Stern Mariana C, Torres-Mejía Gabriela, Wolff Roger K, Slattery Martha L
Abstract excerpt
The cytochrome p450 family 19 gene (CYP19A1) encodes for aromatase, which catalyzes the final step in estrogen biosynthesis and conversion of androgens to estrogens. Genetic variation in CYP19A1 is linked to higher circulating estrogen levels and increased aromatase expression. Using data from the Breast Cancer Health Disparities Study, a consortium of three population-based case-control studies in the United...
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