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Article

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.

Journal of lipid research - 1 Dec 2008

Ishikawa Mayumi, Iwasaki Yuko, Yatoh Shigeru, Kato Toyonori, Kumadaki Shin, Inoue Noriyuki, Yamamoto Takashi, Matsuzaka Takashi, Nakagawa Yoshimi, Yahagi Naoya, Kobayashi Kazuto, Takahashi Akimitsu, Yamada Nobuhiro, Shimano Hitoshi

Abstract excerpt

To determine the role of cholesterol synthesis in pancreatic beta-cells, a transgenic model of in vivo activation of sterol-regulatory element binding protein 2 (SREBP-2) specifically in beta-cells (TgRIP-SREBP-2) was developed and analyzed. Expression of nuclear human SREBP-2 in beta-cells resulted in severe diabetes as evidenced by greater than 5-fold elevations in glycohemoglobin compared with C57BL/6...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18682608
DOI: 10.1194/jlr.M800238-JLR200

Genes

IRS2
PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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