Article
Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2015
Schreiber Renate, Hofer Peter, Taschler Ulrike, Voshol Peter J, Rechberger Gerald N, Kotzbeck Petra, Jaeger Doris, Preiss-Landl Karina, Lord Caleb C, Brown J Mark, Haemmerle Guenter, Zimmermann Robert, Vidal-Puig Antonio, Zechner Rudolf
Abstract excerpt
Adipose triglyceride lipase (ATGL) initiates intracellular triglyceride (TG) catabolism. In humans, ATGL deficiency causes neutral lipid storage disease with myopathy (NLSDM) characterized by a systemic TG accumulation. Mice with a genetic deletion of ATGL (AKO) also accumulate TG in many tissues. However, neither NLSDM patients nor AKO mice are exceedingly obese. This phenotype is unexpected considering the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.