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Article

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

American journal of physiology. Endocrinology and metabolism - 1 Feb 2008

Bao Shunzhong, Jacobson David A, Wohltmann Mary, Bohrer Alan, Jin Wu, Philipson Louis H, Turk John

Abstract excerpt

Studies with genetically modified insulinoma cells suggest that group VIA phospholipase A(2) (iPLA(2)beta) participates in amplifying glucose-induced insulin secretion. INS-1 insulinoma cells that overexpress iPLA(2)beta, for example, exhibit amplified insulin-secretory responses to glucose and cAMP-elevating agents. To determine whether similar effects occur in whole animals, we prepared transgenic (TG) mice in...

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PMID: 17895289
DOI: 10.1152/ajpendo.00474.2007
PMCID: PMC2268609

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