Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies.

American journal of physiology. Endocrinology and metabolism - 1 Feb 2011

Giacca Adria, Xiao Changting, Oprescu Andrei I, Carpentier Andre C, Lewis Gary F

Abstract excerpt

The phenomenon of lipid-induced pancreatic β-cell dysfunction ("lipotoxicity") has been very well documented in numerous in vitro experimental systems and has become widely accepted. In vivo demonstration of β-cell lipotoxicity, on the other hand, has not been consistently demonstrated, and there remains a lack of consensus regarding the in vivo effects of chronically elevated free fatty acids (FFA) on β-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Diabetes Mellitus
Share to Dietary Fats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acids, Nonesterified

Share to Insulin-Secreting Cells

Share to Lipids

Share to Obesity

Share to Pancreatic Diseases

Source

Identifiers

PMID: 21119027
DOI: 10.1152/ajpendo.00416.2010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies.PMID 21119027Read ↗

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetesSemantic proximity Read ↗

Beta cell lipotoxicity in the development of type 2 diabetes: the need for species-specific understandingSemantic proximity Read ↗

Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase.Semantic proximity Read ↗

Lipid droplets protect human β cells from lipotoxic-induced stress and cell identity changesSemantic proximity Read ↗

Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell DysfunctionSemantic proximity Read ↗

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 DiabetesSemantic proximity Read ↗

Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies.Semantic proximity Read ↗

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.Semantic proximity Read ↗

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human IsletsSemantic proximity Read ↗

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.Semantic proximity Read ↗

The beta-cell in human type 2 diabetes.Semantic proximity Read ↗

Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.