Article
Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency. Islet LPL regulates insulin secretion.
The Journal of biological chemistry - 24 Sept 1999
Marshall B A, Tordjman K, Host H H, Ensor N J, Kwon G, Marshall C A, Coleman T, McDaniel M L, Semenkovich C F
Abstract excerpt
Lipoprotein lipase (LPL) provides tissues with fatty acids, which have complex effects on glucose utilization and insulin secretion. To determine if LPL has direct effects on glucose metabolism, we studied mice with heterozygous LPL deficiency (LPL+/-). LPL+/- mice had mean fasting glucose values that were up to 39 mg/dl lower than LPL+/+ littermates. Despite having lower glucose levels, LPL+/- mice had fasting...
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