Article
Regulation of hormone-sensitive lipase in islets.
Diabetes research and clinical practice - 1 Jan 2007
Shen Wen-Jun, Liang Yu, Wang Jenny, Harada Kenji, Patel Shailja, Michie Sara A, Osuga Jun-Ichi, Ishibashi Shun, Kraemer Fredric B
Abstract excerpt
An unique isoform of hormone-sensitive lipase (HSL) is expressed in beta-cells. Recent findings suggest that HSL could be involved in the regulation of glucose stimulated insulin secretion (GSIS), however, these findings are controversial. To test the hypothesis that HSL is involved in control of normal GSIS via changes in its expression and/or activity in response to stimuli, we examined the effects of free...
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