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Beta cell lipotoxicity in the development of type 2 diabetes: the need for species-specific understanding

8 Dec 2023

Abstract excerpt

The propensity to develop type 2 diabetes (T2D) is known to have both environmental and hereditary components. In those with a genetic predisposition to T2D, it is widely believed that elevated concentrations of circulatory long-chain fatty acids (LC-FFA) significantly contribute towards the demise of insulin-producing pancreatic β-cells – the fundamental feature of the development of T2D. Over 25 years of...

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Share to Diabetes and associated disorders
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PMID: 38144558
DOI: 10.3389/fendo.2023.1275835

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