Article

Lipid droplets protect human β cells from lipotoxic-induced stress and cell identity changes

2021-06-20

Abstract excerpt

Free fatty acids (FFAs) are often stored in lipid droplet (LD) depots for eventual metabolic and/or synthetic use in many cell types, such a muscle, liver, and fat. In pancreatic islets, overt LD accumulation was detected in humans but not mice. LD buildup in islets was principally observed after roughly 11 years of age, increasing throughout adulthood under physiologic conditions, and also enriched in type 2 diab...

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Literature Corpus work: 1a09ec84-970c-5182-a15b-aaf56832a05e
DOI: 10.1101/2021.06.19.449124

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