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Article

Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells

1 Feb 2005

Abstract excerpt

Influx of excess fatty acids and the resultant accumulation of intracellular triglycerides are linked to impaired insulin secretion and action in the pathogenesis of type 2 diabetes. Sterol regulatory element-binding protein (SREBP)-1c is a transcription factor that controls cellular synthesis of fatty acids and triglycerides. SREBP-1c is highly expressed in high-energy and insulin-resistant states. To...

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Share to Cholesterol and Lipid Metabolism
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Identifiers

PMID: 15677507
DOI: 10.2337/diabetes.54.2.492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-CellsPMID 15677507Read ↗

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